Cadis E. di Raizel, the noblest of all vampires, who wakes up from 820-years long sleep and starts a new life as a high school student. His peaceful days as a student are soon interrupted by a group of attackers known as the "Unions." Noblesse follows Raizel and his loyal servant, Frankenstein, as they constantly protect and save Raizel's new human friends from the mysterious threats.